Research in the Clift Group

Research in the Clift group focuses heavily on the development of new catalytic methods for organic synthesis.  In biological systems, enzymatic cofactors display a seemingly limitless array of powerful organic reactivity.  By harnessing the potential of these unique organic molecules in abiotic environments, we seek to discover novel synthetic strategies that will enable a diverse range of enantioselective transformations. 

Specifically, we are interested in the development of new organocatalytic reaction manifolds that will enable a variety of C−C bond forming events through inert bond functionalization. The successful pursuit of these goals is expected to deliver synthetic methods that will facilitate previously challenging or even impossible chemical transformations.  In a broader context, this work will ultimately accelerate the construction of biologically relevant natural products and other medicinal agents by providing new means for the strategic disconnection of these valuable synthetic targets. 

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